United battle back to rock Blackpool
Sir Alex Ferguson's team had gone 27 league games without losing, run back to the 2-1 defeat against Chelsea last season in April.
But the sequence seemed in danger as the goals of the former United defender Craig Cathcart and striker DJ Campbell put the Seasiders 2-0 up at half time.
Blackpool could have had a penalty when Luke Varney was wound onto the roof of Rafael da Silva at the start of the second half.
But United finally a time when the Bulgarian Dimitar Berbatov volley as home of Darren Fletcher on 72 minutes.
Mexico striker Javier Hernandez, Wayne Rooney tied slow when found in a Ryan Giggs pass and slotted past Richard Kingson on 74 minutes.
United right-back Rafael has been evacuated on a stretcher after lengthy treatment on a head wound, but Berbatov stole the points in the 88th minute when he drove over Kingson to leave the leaders and ahead of second place Arsenal.
In other fighting Tuesday's Premier League, won 2-1 at Aston Villa Wigan lower third move six points away from the relegation zone.
Gabriel Agbonlahor opened the scoring on 49 minutes when he headed home from Ali Al Habsi saved Carlos Cuellar header.
Gerard Houllier's side that beat Manchester City on Saturday, wrapped up 62 points minute when Ashley Young converted a penalty after a foul Hendry Thomas.
James McCarthy deflected effort reduced the deficit in the 80th minute but it was too late for Wigan to save a draw.